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Summary

Lifecycle: reviewedEditUnder review
What this benchmark means
README.md

Public entries: Python and R. Passing coverage requires an installed inventory.

Goal: relate each medication to the adverse events it was given for, carrying IDVARVAL, RELTYPE, and RELID.

Input: adverse event (AE) records with their assigned sequence number (AESEQ) and the event number collected on the form (AESPID), and concomitant medication (CM) records with their assigned sequence number (CMSEQ) and up to two event numbers entered on the medication form as the events it treated (CMAENO1, CMAENO2). The link is collected on the medication form only.

Variables:

  • IDVARVAL is the sequence number of the related record as text: CMSEQ on a medication row and, on an event row, the AESEQ of the same subject's adverse event whose collected event number matches, never the collected number itself.
  • RELTYPE is blank throughout, because each row points at one record rather than a whole dataset.
  • RELID numbers the subject's medication and event pairs 1, 2, 3 and so on, in adverse event sequence order and then medication sequence order; the two rows of one pair share it.

Note: each event number on a medication record gives one relationship of two rows, one for the medication and one for the event, so a medication given for two events takes part in two relationships, as does an event treated by two medications. Event numbers match within the same subject only. A medication without an event number, and an event no medication names, contribute no row. An event number that names no adverse event of that subject stops the run, and so does a medication repeating one event number in both fields, which would state the same relationship twice.

Inputs

Under review
2 source files

input/ae.csv

Edit
4 rows
input/ae.csv
STUDYIDUSUBJIDAESEQAESPIDAETERM
CATH12HEADACHE
CATH21NAUSEA
CATH33RASH
CATH11DIZZINESS

input/cm.csv

Edit
5 rows
input/cm.csv
STUDYIDUSUBJIDCMSEQCMTRTCMAENO1CMAENO2
CATH1IBUPROFEN2—
CATH2ONDANSETRON1—
CATH3METOCLOPRAMIDE12
CATH4MULTIVITAMIN——
CATH1MECLIZINE1—

Expected output

Under review
10 expected rows

expected/relrec.csv

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10 rows
expected/relrec.csv
STUDYIDUSUBJIDRDOMAINIDVARIDVARVALRELTYPERELID
CATHAEAESEQ1—1
CATHCMCMSEQ1—1
CATHAEAESEQ1—2
CATHCMCMSEQ3—2
CATHAEAESEQ2—3
CATHCMCMSEQ2—3
CATHAEAESEQ2—4
CATHCMCMSEQ3—4
CATHAEAESEQ1—1
CATHCMCMSEQ1—1
Shaded columns are derived— = missing value

Human review and assessment

Your review

3 questions and your comments · View benchmark discussions

Mapping spec

Generated from the benchmark YAML; do not edit by hand

Variable NameVariable LabelTypeLengthControlled Terms or FormatOriginCoreConversion DefinitionVariable TypeVariable OrderComments for Define
STUDYIDStudy IdentifierCharCollectedCopy value from CM.STUDYID.SDTM1
USUBJIDUnique Subject IdentifierCharCollectedCopy value from CM.USUBJID.SDTM2
RDOMAINRelated Domain AbbreviationCharDerivedSet per constructed row; see the Row construction sheet.SDTM3
IDVARIdentifying VariableCharDerivedSet per constructed row; see the Row construction sheet.SDTM4
RELTYPERelationship TypeCharAssignedSet constant value "None".SDTM5
IDVARVALIdentifying Variable ValueCharDerivedSet per constructed row; see the Row construction sheet.SDTM6
RELIDRelationship IdentifierCharDerivedCopy value from RELNUM.SDTM7
TemplateInclude whenRDOMAINIDVARIDVARVALPAIRAE
cm_reference_1CM.CMAENO1 IS NOT NULLConstant "CM"Constant "CMSEQ"Copy CM.CMSEQIf CM.CMAENO1 IS NOT NULL then "AE_REF1.AESEQ"; otherwise blank
ae_reference_1CM.CMAENO1 IS NOT NULLConstant "AE"Constant "AESEQ"Copy PAIRAEIf CM.CMAENO1 IS NOT NULL then "AE_REF1.AESEQ"; otherwise blank
cm_reference_2CM.CMAENO2 IS NOT NULLConstant "CM"Constant "CMSEQ"Copy CM.CMSEQIf CM.CMAENO2 IS NOT NULL then "AE_REF2.AESEQ"; otherwise blank
ae_reference_2CM.CMAENO2 IS NOT NULLConstant "AE"Constant "AESEQ"Copy PAIRAEIf CM.CMAENO2 IS NOT NULL then "AE_REF2.AESEQ"; otherwise blank
VersionDateAuthorDescriptionReviewerSign-off
1.72026-10-20yamaa docs buildRead a specification in the 1.0 surface as its 0.5 counterpart; state that missing values stay missing where a mapping declares no missing handler, and leave out a declared missing answer that restates a handler's default
1.62026-10-17yamaa docs buildDescribe collected date parts written as ISO 8601 date text and times of day counted in seconds since midnight
1.52026-10-17yamaa docs buildName collected precision in words instead of letter codes; state imputation fallbacks, minimum source precision, bounds ignored outside the collected period, and invalid text with no handler as an error; describe date and datetime shifts, imputation flag codes, and partial text giving no date part
1.42026-10-15yamaa docs buildState datetime precision codes through the hour and minute, and complete only the time parts a collected datetime lacks
1.32026-09-29yamaa docs buildShow study codelist names, external dictionaries, and ISO 8601 formats in variable rows; list the document's codelist values and metadata
1.22026-09-29yamaa docs buildClassify ADaM copies from a declared input as Predecessor and recodes as Derived, and SDTM recodes of locally derived columns as Derived
1.12026-09-29yamaa docs buildResolve lookups into the donor record they select, and give every derivation shape a plain-language rule instead of its raw YAML
1.0yamaa docs buildInitial generation from spec.yaml

Agent prompt

The request an agent receives with the input files; each tier states no more than the one above

prompts/sdtm-relrec-links/full.md

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23 lines

Following CDISC SDTM standards, use the provided AE and CM datasets to create a RELREC dataset with one record per relationship participation.

The output dataset should contain the following columns in this order: STUDYID, USUBJID, RDOMAIN, IDVAR, IDVARVAL, RELTYPE, RELID

The link between a medication and an adverse event is collected on the medication form only: CMAENO1 and CMAENO2 hold up to two adverse event numbers, each naming the AE record of the same subject whose AESPID equals it. Each event number on a CM record gives one relationship of two rows: a row for the CM record, with RDOMAIN "CM", IDVAR "CMSEQ" and IDVARVAL its CMSEQ, and a row for the AE record it names, with RDOMAIN "AE", IDVAR "AESEQ" and IDVARVAL that AE record's AESEQ, not the event number. IDVARVAL is the sequence number as text. A medication given for two events takes part in two relationships, and an event treated by two medications likewise. A CM record with no event number, and an AE record no medication names, give no row. RELTYPE has no value on any row, because each row points at one record rather than a whole dataset. RELID numbers the relationships within each subject 1, 2, 3 and so on, ordered by the AESEQ of the event and then the CMSEQ of the medication; the two rows of one relationship share it.

Read the source datasets from /app/input and save the completed dataset as /app/output/relrec.csv.

prompts/sdtm-relrec-links/conventions.md

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13 lines

Following CDISC SDTM standards, use the provided AE and CM datasets to create a RELREC dataset with one record per relationship participation.

The output dataset should contain the following columns in this order: STUDYID, USUBJID, RDOMAIN, IDVAR, IDVARVAL, RELTYPE, RELID

IDVAR is "AESEQ" or "CMSEQ". RELTYPE has no value on any row. RELID numbers the relationships within each subject 1, 2, 3 and so on, ordered by the AESEQ of the event and then the CMSEQ of the medication; the two rows of one relationship share it.

Read the source datasets from /app/input and save the completed dataset as /app/output/relrec.csv.

prompts/sdtm-relrec-links/brief.md

Edit
8 lines

Following CDISC SDTM standards, use the provided AE and CM datasets to create a RELREC dataset with one record per relationship participation.

The output dataset should contain the following columns in this order: STUDYID, USUBJID, RDOMAIN, IDVAR, IDVARVAL, RELTYPE, RELID

Read the source datasets from /app/input and save the completed dataset as /app/output/relrec.csv.

yamaa code

Public calls generated from benchmark.yaml; results must match the expected output

R

Edit
3 lines
library(yamaa)yamaa_spec("spec.yaml")$run()$output

Python

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3 lines
import yamaayamaa.spec("spec.yaml").run().output

Solution without yamaa

Written from the full prompt and the inputs alone; CI checks it reproduces the expected output

solutions/sdtm-relrec-links/result.R

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66 lines
# Reference solution for the yamaa benchmark sdtm-relrec-links (R track).## Written from the benchmark's full prompt and its inputs alone, as an agent# would write it. Harbor's oracle agent runs it to check that the prompt can# be solved and that the grader scores a correct answer 1.library(dplyr, warn.conflicts = FALSE)library(readr)library(tidyr)ae <- read_csv(  "/app/input/ae.csv",  col_types = cols(.default = col_character()))cm <- read_csv(  "/app/input/cm.csv",  col_types = cols(.default = col_character()))ae_numbers <- ae |>  transmute(    STUDYID, USUBJID,    AENO = trimws(AESPID),    AESEQ = as.integer(AESEQ)  )# Each event number on a medication record names the same subject's AE# record with that AESPID; every number must name one.pairs <- cm |>  pivot_longer(    cols = c(CMAENO1, CMAENO2),    values_to = "AENO"  ) |>  mutate(AENO = trimws(AENO)) |>  filter(!is.na(AENO) & AENO != "") |>  inner_join(    ae_numbers,    by = c("STUDYID", "USUBJID", "AENO"),    unmatched = c("error", "drop"),    relationship = "many-to-one"  ) |>  mutate(CMSEQ = as.integer(CMSEQ)) |>  arrange(STUDYID, USUBJID, AESEQ, CMSEQ) |>  group_by(STUDYID, USUBJID) |>  mutate(RELID = as.character(row_number())) |>  ungroup()ae_rows <- pairs |>  transmute(    STUDYID, USUBJID,    RDOMAIN = "AE", IDVAR = "AESEQ", IDVARVAL = as.character(AESEQ),    RELTYPE = NA_character_, RELID  )cm_rows <- pairs |>  transmute(    STUDYID, USUBJID,    RDOMAIN = "CM", IDVAR = "CMSEQ", IDVARVAL = as.character(CMSEQ),    RELTYPE = NA_character_, RELID  )relrec <- bind_rows(ae_rows, cm_rows) |>  arrange(USUBJID, as.integer(RELID), RDOMAIN) |>  select(STUDYID, USUBJID, RDOMAIN, IDVAR, IDVARVAL, RELTYPE, RELID)dir.create("/app/output", showWarnings = FALSE)write_csv(relrec, "/app/output/relrec.csv", na = "")

solutions/sdtm-relrec-links/result.py

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80 lines
# Reference solution for the yamaa benchmark sdtm-relrec-links (Python track).## Written from the benchmark's full prompt and its inputs alone, as an agent# would write it. Harbor's oracle agent runs it to check that the prompt can# be solved and that the grader scores a correct answer 1."""Build a RELREC dataset from the AE numbers entered on CM records.Each event number in CMAENO1/CMAENO2 names the same subject's AE recordwith that AESPID. Every such medication-event pair gives two RELREC rows,one for the CM record and one for the AE record, sharing a RELID thatnumbers the subject's pairs by AESEQ and then CMSEQ."""import csvimport osINPUT_DIR = "/app/input"OUTPUT_DIR = "/app/output"COLUMNS = ["STUDYID", "USUBJID", "RDOMAIN", "IDVAR", "IDVARVAL",           "RELTYPE", "RELID"]def read_rows(name):    with open(os.path.join(INPUT_DIR, name), newline="",              encoding="utf-8") as handle:        return list(csv.DictReader(handle))def clean(value):    return "" if value is None else value.strip()def main():    ae = read_rows("ae.csv")    cm = read_rows("cm.csv")    aeseq_by_number = {}    for record in ae:        key = (record["STUDYID"], record["USUBJID"], clean(record["AESPID"]))        aeseq_by_number[key] = int(record["AESEQ"])    pairs = {}    for record in cm:        subject = (record["STUDYID"], record["USUBJID"])        cmseq = int(record["CMSEQ"])        for var in ("CMAENO1", "CMAENO2"):            number = clean(record.get(var))            if not number:                continue            aeseq = aeseq_by_number[subject + (number,)]            pairs.setdefault(subject, []).append((aeseq, cmseq))    rows = []    for subject in sorted(pairs):        studyid, usubjid = subject        for relid, (aeseq, cmseq) in enumerate(sorted(pairs[subject]), 1):            for rdomain, idvar, seq in (("AE", "AESEQ", aeseq),                                        ("CM", "CMSEQ", cmseq)):                rows.append({                    "STUDYID": studyid,                    "USUBJID": usubjid,                    "RDOMAIN": rdomain,                    "IDVAR": idvar,                    "IDVARVAL": str(seq),                    "RELTYPE": "",                    "RELID": str(relid),                })    os.makedirs(OUTPUT_DIR, exist_ok=True)    out_path = os.path.join(OUTPUT_DIR, "relrec.csv")    with open(out_path, "w", newline="", encoding="utf-8") as handle:        writer = csv.DictWriter(handle, fieldnames=COLUMNS)        writer.writeheader()        writer.writerows(rows)if __name__ == "__main__":    main()

solutions/sdtm-relrec-links/result.sas

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53 lines
/* opensas reference solution for the yamaa benchmark sdtm-relrec-links.   Reads the benchmark inputs and derives the requested output.   Execute with the existing opensas runtime: opensas /app/output/result.sas. */data ae;  length STUDYID USUBJID AESPID AETERM $1024;  infile "/app/input/ae.csv" dsd dlm="," firstobs=2 truncover lrecl=32767;  input STUDYID : $char1024. USUBJID : $char1024. AESEQ AESPID : $char1024. AETERM : $char1024.;run;data cm;  length STUDYID USUBJID CMTRT CMAENO1 CMAENO2 $1024;  infile "/app/input/cm.csv" dsd dlm="," firstobs=2 truncover lrecl=32767;  input STUDYID : $char1024. USUBJID : $char1024. CMSEQ CMTRT : $char1024. CMAENO1 : $char1024. CMAENO2 : $char1024.;run;data refs; set cm; length AENO $1024;if not missing(CMAENO1) then do; AENO=strip(CMAENO1); output; end;if not missing(CMAENO2) then do; AENO=strip(CMAENO2); output; end;keep STUDYID USUBJID CMSEQ AENO;run;proc sql;  create table matched as  select r.STUDYID, r.USUBJID, a.AESEQ, r.CMSEQ, a.AESPID as MATCHED_AENO  from refs as r left join ae as a    on r.STUDYID=a.STUDYID and r.USUBJID=a.USUBJID and r.AENO=strip(a.AESPID)  order by r.STUDYID, r.USUBJID, a.AESEQ, r.CMSEQ;quit;/* A populated reference must name an event before any output is written. */data pairs; set matched;if missing(MATCHED_AENO) then abort return 1;drop MATCHED_AENO;run;data numbered; set pairs; by STUDYID USUBJID;if first.USUBJID then RELNUM=0;RELNUM+1;run;data result; set numbered;length RDOMAIN IDVAR IDVARVAL RELTYPE RELID $1024;RELTYPE=''; RELID=strip(put(RELNUM,best32.));RDOMAIN='AE'; IDVAR='AESEQ'; IDVARVAL=strip(put(AESEQ,best32.)); output;RDOMAIN='CM'; IDVAR='CMSEQ'; IDVARVAL=strip(put(CMSEQ,best32.)); output;run;proc sql;  create table final as select STUDYID, USUBJID, RDOMAIN, IDVAR, IDVARVAL, RELTYPE, RELID  from result order by STUDYID, USUBJID, RELNUM, RDOMAIN;quit;proc export data=final outfile="/app/output/relrec.csv" dbms=csv replace; run;