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- Task: Would a real study need this derivation, specified this way? Does it follow CDISC SDTM: variable names, controlled terms, record structure? Flag any rule that is ambiguous or that a sponsor would handle differently.
- Inputs: Do they look like data collected in a real trial, and do they include the situations you would expect to meet in one?
- Expected output: Would independent QC programming reproduce every value from these inputs and rules?
The other tabs beside Comments are background for assessment, not under review.
Summary
README.mdGoal: build one record per collected calcium and creatinine
result with LBTESTCD, LBTEST, LBORRES, LBORRESU,
LBSTRESN, LBSTRESU, LBSTAT and LBDTC.
Input: long-form Operational Data Model (ODM) rows, one row per collected item, grouped by study, subject and visit. Each visit group carries a collection-date item plus one calcium item and one creatinine item, whichever were collected.
Variables:
LBSEQnumbers the records within a subject by collection date, then test code.LBTESTCDisCAfor calcium rows andCREATfor creatinine rows.LBTESTisCalciumwhen the test code isCAandCreatininewhen it isCREAT.LBORRESis the collected entry, kept exactly as reported; empty when the test was not done.LBORRESUismg/dLfor every record with a result; empty when the test was not done.LBSTRESNis the numeric form of the collected entry; missing when the entry is text rather than a number, or when the test was not done.LBSTRESUismg/dLfor every record with a result; empty when the test was not done.LBSTATisNOT DONEwhen the collected entry says the test was not done; blank otherwise.LBDTCis the collection date from the same visit group.
Note: a test with no collected entry produces no record, so
the records are only results actually reported. A NOT DONE
entry does produce a record: the result and units stay
empty and LBSTAT carries NOT DONE.
Inputs
Under review1 source fileinput/odm.csv
Edit17 rows| StudyOID | MetaDataVersionOID | SubjectKey | StudyEventOID | StudyEventRepeatKey | ItemGroupOID | ItemGroupRepeatKey | ItemOID | Value |
|---|---|---|---|---|---|---|---|---|
| YAMAA-01 | MDV.1 | YAMAA-01-101 | BASELINE | 1 | IG.LB | 1 | IT.LB.LBDTC | 2025-01-01 |
| YAMAA-01 | MDV.1 | YAMAA-01-101 | BASELINE | 1 | IG.LB | 1 | IT.LB.CALCIUM | 9.2 |
| YAMAA-01 | MDV.1 | YAMAA-01-101 | BASELINE | 1 | IG.LB | 1 | IT.LB.CREAT | 0.8 |
| YAMAA-01 | MDV.1 | YAMAA-01-101 | DAY8 | 1 | IG.LB | 1 | IT.LB.LBDTC | 2025-01-08 |
| YAMAA-01 | MDV.1 | YAMAA-01-101 | DAY8 | 1 | IG.LB | 1 | IT.LB.CALCIUM | — |
| YAMAA-01 | MDV.1 | YAMAA-01-101 | DAY8 | 1 | IG.LB | 1 | IT.LB.CREAT | 0.9 |
| YAMAA-01 | MDV.1 | YAMAA-01-101 | DAY15 | 1 | IG.LB | 1 | IT.LB.LBDTC | 2025-01-15 |
| YAMAA-01 | MDV.1 | YAMAA-01-101 | DAY15 | 1 | IG.LB | 1 | IT.LB.CREAT | NOT DONE |
| YAMAA-01 | MDV.1 | YAMAA-01-102 | BASELINE | 1 | IG.LB | 1 | IT.LB.LBDTC | 2025-02-03 |
| YAMAA-01 | MDV.1 | YAMAA-01-102 | BASELINE | 1 | IG.LB | 1 | IT.LB.CALCIUM | 10.1 |
| YAMAA-01 | MDV.1 | YAMAA-01-102 | BASELINE | 1 | IG.LB | 1 | IT.LB.CREAT | 1.1 |
| YAMAA-01 | MDV.1 | YAMAA-01-103 | BASELINE | 1 | IG.LB | 1 | IT.LB.LBDTC | 2025-03-10 |
| YAMAA-01 | MDV.1 | YAMAA-01-103 | BASELINE | 1 | IG.LB | 1 | IT.LB.CALCIUM | 8.4 |
| YAMAA-01 | MDV.1 | YAMAA-01-103 | BASELINE | 1 | IG.LB | 1 | IT.LB.CREAT | 1.3 |
| YAMAA-01 | MDV.1 | YAMAA-01-103 | DAY8 | 1 | IG.LB | 1 | IT.LB.LBDTC | 2025-03-17 |
| YAMAA-01 | MDV.1 | YAMAA-01-103 | DAY8 | 1 | IG.LB | 1 | IT.LB.CALCIUM | 10.5 |
| YAMAA-01 | MDV.1 | YAMAA-01-103 | DAY8 | 1 | IG.LB | 1 | IT.LB.CREAT | — |
Expected output
Under review9 expected rowsexpected/lb.csv
Edit9 rows| DOMAIN | STUDYID | USUBJID | LBSEQ | LBTESTCD | LBTEST | LBORRES | LBORRESU | LBSTRESN | LBSTRESU | LBSTAT | LBDTC |
|---|---|---|---|---|---|---|---|---|---|---|---|
| LB | YAMAA-01 | 1 | CA | Calcium | 9.2 | mg/dL | 9.2 | mg/dL | — | 2025-01-01 | |
| LB | YAMAA-01 | 1 | CA | Calcium | 10.1 | mg/dL | 10.1 | mg/dL | — | 2025-02-03 | |
| LB | YAMAA-01 | 1 | CA | Calcium | 8.4 | mg/dL | 8.4 | mg/dL | — | 2025-03-10 | |
| LB | YAMAA-01 | 3 | CA | Calcium | 10.5 | mg/dL | 10.5 | mg/dL | — | 2025-03-17 | |
| LB | YAMAA-01 | 2 | CREAT | Creatinine | 0.8 | mg/dL | 0.8 | mg/dL | — | 2025-01-01 | |
| LB | YAMAA-01 | 3 | CREAT | Creatinine | 0.9 | mg/dL | 0.9 | mg/dL | — | 2025-01-08 | |
| LB | YAMAA-01 | 4 | CREAT | Creatinine | — | — | — | — | NOT DONE | 2025-01-15 | |
| LB | YAMAA-01 | 2 | CREAT | Creatinine | 1.1 | mg/dL | 1.1 | mg/dL | — | 2025-02-03 | |
| LB | YAMAA-01 | 2 | CREAT | Creatinine | 1.3 | mg/dL | 1.3 | mg/dL | — | 2025-03-10 |
Comments and assessment materials
| Variable Name | Variable Label | Type | Length | Controlled Terms or Format | Origin | Core | Conversion Definition | Variable Type | Variable Order | Comments for Define |
|---|---|---|---|---|---|---|---|---|---|---|
| DOMAIN | Domain Abbreviation | Char | Assigned | Set constant value "LB". | SDTM | 1 | ||||
| STUDYID | Study Identifier | Char | Collected | Copy value from ODM.StudyOID. | SDTM | 2 | ||||
| USUBJID | Unique Subject Identifier | Char | Collected | Copy value from ODM.SubjectKey. | SDTM | 3 | ||||
| LBORRES | Result or Finding in Original Units | Char | Derived | If RAWORRES = 'NOT DONE' then "None"; otherwise "RAWORRES". | SDTM | 4 | ||||
| LBORRESU | Original Units | Char | Derived | If RAWORRES = 'NOT DONE' then "None"; otherwise "mg/dL". | SDTM | 5 | ||||
| LBSTRESU | Standard Units | Char | Derived | If RAWORRES = 'NOT DONE' then "None"; otherwise "mg/dL". | SDTM | 6 | ||||
| LBSTAT | Completion Status | Char | NOT DONE | Derived | If RAWORRES = 'NOT DONE' then "NOT DONE"; otherwise blank. | SDTM | 7 | |||
| LBTESTCD | Lab Test or Examination Short Name | Char | Derived | Set per constructed row; see the Row construction sheet. | SDTM | 8 | ||||
| LBTEST | Lab Test or Examination Name | Char | Derived | Set per constructed row; see the Row construction sheet. | SDTM | 9 | ||||
| LBSTRESN | Numeric Result/Finding in Standard Units | Num | Derived | Copy value from LBORRES; a value that cannot be converted → blank. | SDTM | 10 | ||||
| LBDTC | Date/Time of Specimen Collection | Char | ISO 8601 | Derived | Set per constructed row; see the Row construction sheet. | SDTM | 11 | |||
| LBSEQ | Sequence Number | Num | Derived | Row number within each group of STUDYID, USUBJID, ordered by LBDTC then LBTESTCD. | SDTM | 12 |
| Template | Include when | LBTESTCD | LBTEST | RAWORRES | LBDTC |
|---|---|---|---|---|---|
| calcium | RAWORRES IS NOT NULL | Constant "CA" | Constant "Calcium" | Aggregate ONLY(ODM.Value) over records matching on the shared output keys, where ODM.ItemOID = 'IT.LB.CALCIUM' | Aggregate ONLY(ODM.Value) over records matching on the shared output keys, where ODM.ItemOID = 'IT.LB.LBDTC' |
| creatinine | RAWORRES IS NOT NULL | Constant "CREAT" | Constant "Creatinine" | Aggregate ONLY(ODM.Value) over records matching on the shared output keys, where ODM.ItemOID = 'IT.LB.CREAT' | Aggregate ONLY(ODM.Value) over records matching on the shared output keys, where ODM.ItemOID = 'IT.LB.LBDTC' |
| Variable | Permitted values |
|---|---|
| LBSTAT | NOT DONE |
| Version | Date | Author | Description | Reviewer | Sign-off |
|---|---|---|---|---|---|
| 1.3 | 2026-09-29 | yamaa docs build | Show study codelist names, external dictionaries, and ISO 8601 formats in variable rows; list the document's codelist values and metadata | ||
| 1.2 | 2026-09-29 | yamaa docs build | Classify ADaM copies from a declared input as Predecessor and recodes as Derived, and SDTM recodes of locally derived columns as Derived | ||
| 1.1 | 2026-09-29 | yamaa docs build | Resolve lookups into the donor record they select, and give every derivation shape a plain-language rule instead of its raw YAML | ||
| 1.0 | yamaa docs build | Initial generation from spec.yaml |
prompts/sdtm-lb-findings/full.md
Edit28 linesFollowing CDISC SDTM standards, use the provided ODM dataset to create an LB dataset with one record per collected calcium and creatinine result.
The output dataset should contain the following columns in this order: DOMAIN, STUDYID, USUBJID, LBSEQ, LBTESTCD, LBTEST, LBORRES, LBORRESU, LBSTRESN, LBSTRESU, LBSTAT, LBDTC
STUDYID is the ODM StudyOID and USUBJID is the SubjectKey, each as given.
LBSEQ numbers the records within a subject by collection date, then test code. LBTESTCD is CA for calcium rows and CREAT for creatinine rows; LBTEST is Calcium when the test code is CA and Creatinine when it is CREAT.
LBORRES is the collected entry, kept exactly as reported, and has no value when the test was not done. LBORRESU and LBSTRESU are mg/dL for every record with a result, and have no value when the test was not done. LBSTRESN is the numeric form of the collected entry, and has no value when the entry is text rather than a number or when the test was not done. LBSTAT is NOT DONE when the collected entry says the test was not done, and has no value otherwise. LBDTC is the collection date from the same visit group.
A test with no collected entry produces no record. An entry of NOT DONE does produce a record, with no value in the result and unit fields.
Read the source datasets from /app/input and save the completed dataset as /app/output/lb.csv.
prompts/sdtm-lb-findings/conventions.md
Edit14 linesFollowing CDISC SDTM standards, use the provided ODM dataset to create an LB dataset with one record per collected calcium and creatinine result.
The output dataset should contain the following columns in this order: DOMAIN, STUDYID, USUBJID, LBSEQ, LBTESTCD, LBTEST, LBORRES, LBORRESU, LBSTRESN, LBSTRESU, LBSTAT, LBDTC
LBTESTCD is CA for calcium rows and CREAT for creatinine rows; LBTEST is Calcium when the test code is CA and Creatinine when it is CREAT.
LBSTAT is NOT DONE or has no value.
Read the source datasets from /app/input and save the completed dataset as /app/output/lb.csv.
prompts/sdtm-lb-findings/brief.md
Edit9 linesFollowing CDISC SDTM standards, use the provided ODM dataset to create an LB dataset with one record per collected calcium and creatinine result.
The output dataset should contain the following columns in this order: DOMAIN, STUDYID, USUBJID, LBSEQ, LBTESTCD, LBTEST, LBORRES, LBORRESU, LBSTRESN, LBSTRESU, LBSTAT, LBDTC
Read the source datasets from /app/input and save the completed dataset as /app/output/lb.csv.
run.R
Edit4 lineslibrary(yamaa)lb <- yamaa_domain("spec.yaml")$outputlbrun.py
Edit4 linesimport yamaalb = yamaa.yamaa_domain("spec.yaml").outputlbsolutions/sdtm-lb-findings/result.R
Edit55 lines# Reference solution for the yamaa benchmark sdtm-lb-findings (R track).## Written from the benchmark's full prompt and its inputs alone, as an agent# would write it. Harbor's oracle agent runs it to check that the prompt can# be solved and that the grader scores a correct answer 1.library(dplyr, warn.conflicts = FALSE)library(readr)library(tidyr)odm <- read_csv( "/app/input/odm.csv", col_types = cols(.default = col_character()))key_cols <- c( "StudyOID", "SubjectKey", "StudyEventOID", "StudyEventRepeatKey", "ItemGroupOID", "ItemGroupRepeatKey")dates <- odm |> filter(ItemOID == "IT.LB.LBDTC") |> select(all_of(key_cols), LBDTC = Value)lb <- odm |> filter(ItemOID %in% c("IT.LB.CALCIUM", "IT.LB.CREAT")) |> left_join(dates, by = key_cols) |> mutate(Value = na_if(Value, "")) |> filter(!is.na(Value)) |> mutate( LBTESTCD = if_else(ItemOID == "IT.LB.CALCIUM", "CA", "CREAT"), LBTEST = if_else(ItemOID == "IT.LB.CALCIUM", "Calcium", "Creatinine"), NOTDONE = Value == "NOT DONE", DOMAIN = "LB", STUDYID = StudyOID, USUBJID = SubjectKey, LBORRES = if_else(NOTDONE, NA_character_, Value), LBORRESU = if_else(NOTDONE, NA_character_, "mg/dL"), LBSTRESN = if_else( NOTDONE, NA_real_, suppressWarnings(as.numeric(Value)) ), LBSTRESU = if_else(NOTDONE, NA_character_, "mg/dL"), LBSTAT = if_else(NOTDONE, "NOT DONE", NA_character_) ) |> arrange(STUDYID, USUBJID, LBDTC, LBTESTCD) |> group_by(STUDYID, USUBJID) |> mutate(LBSEQ = row_number()) |> ungroup() |> select( DOMAIN, STUDYID, USUBJID, LBSEQ, LBTESTCD, LBTEST, LBORRES, LBORRESU, LBSTRESN, LBSTRESU, LBSTAT, LBDTC )dir.create("/app/output", showWarnings = FALSE)write_csv(lb, "/app/output/lb.csv", na = "")solutions/sdtm-lb-findings/result.py
Edit113 lines# Reference solution for the yamaa benchmark sdtm-lb-findings (Python track).## Written from the benchmark's full prompt and its inputs alone, as an agent# would write it. Harbor's oracle agent runs it to check that the prompt can# be solved and that the grader scores a correct answer 1.from pathlib import Pathimport polars as plodm = pl.read_csv("/app/input/odm.csv", infer_schema=False)key_cols = [ "StudyOID", "SubjectKey", "StudyEventOID", "StudyEventRepeatKey", "ItemGroupOID", "ItemGroupRepeatKey",]wide = ( odm.group_by(key_cols) .agg(pl.struct("ItemOID", "Value").alias("items")) .with_columns( pl.col("items") .list.eval( pl.element().filter( pl.element().struct.field("ItemOID") == "IT.LB.LBDTC" ) ) .list.get(0) .struct.field("Value") .alias("LBDTC"), ) .drop("items"))tests = odm.filter(pl.col("ItemOID").is_in(["IT.LB.CALCIUM", "IT.LB.CREAT"]))code_of = {"IT.LB.CALCIUM": "CA", "IT.LB.CREAT": "CREAT"}name_of = {"CA": "Calcium", "CREAT": "Creatinine"}joined = tests.join(wide, on=key_cols, how="left")def as_number(text): if text is None or text == "" or text == "NOT DONE": return None try: return float(text) except ValueError: return Nonerows = []for r in joined.to_dicts(): value = r["Value"] # A test with no collected entry produces no record. if value is None or value == "": continue code = code_of[r["ItemOID"]] not_done = value == "NOT DONE" rows.append( { "DOMAIN": "LB", "STUDYID": r["StudyOID"], "USUBJID": r["SubjectKey"], "LBDTC": r["LBDTC"], "LBTESTCD": code, "LBTEST": name_of[code], "LBORRES": None if not_done else value, "LBORRESU": None if not_done else "mg/dL", "LBSTRESN": None if not_done else as_number(value), "LBSTRESU": None if not_done else "mg/dL", "LBSTAT": "NOT DONE" if not_done else None, } )lb = pl.DataFrame( rows, schema={ "DOMAIN": pl.String, "STUDYID": pl.String, "USUBJID": pl.String, "LBDTC": pl.String, "LBTESTCD": pl.String, "LBTEST": pl.String, "LBORRES": pl.String, "LBORRESU": pl.String, "LBSTRESN": pl.Float64, "LBSTRESU": pl.String, "LBSTAT": pl.String, },).sort(["STUDYID", "USUBJID", "LBDTC", "LBTESTCD"]).with_columns( pl.int_range(1, pl.len() + 1).over(["STUDYID", "USUBJID"]).alias("LBSEQ")).select( "DOMAIN", "STUDYID", "USUBJID", "LBSEQ", "LBTESTCD", "LBTEST", "LBORRES", "LBORRESU", "LBSTRESN", "LBSTRESU", "LBSTAT", "LBDTC",)Path("/app/output").mkdir(parents=True, exist_ok=True)lb.write_csv("/app/output/lb.csv")solutions/sdtm-lb-findings/result.sas
Edit40 lines/* opensas reference solution for the yamaa benchmark sdtm-lb-findings. Reads the benchmark inputs and derives the requested output. Execute with the existing opensas runtime: opensas /app/output/result.sas. */data odm; length StudyOID MetaDataVersionOID SubjectKey StudyEventOID StudyEventRepeatKey ItemGroupOID ItemGroupRepeatKey ItemOID Value $1024; infile "/app/input/odm.csv" dsd dlm="," firstobs=2 truncover lrecl=32767; input StudyOID : $char1024. MetaDataVersionOID : $char1024. SubjectKey : $char1024. StudyEventOID : $char1024. StudyEventRepeatKey : $char1024. ItemGroupOID : $char1024. ItemGroupRepeatKey : $char1024. ItemOID : $char1024. Value : $char1024.;run;proc sort data=odm out=ordered; by StudyOID SubjectKey StudyEventOID StudyEventRepeatKey ItemGroupRepeatKey; run;data dates; length LBDTC $1024; retain LBDTC; set ordered; by StudyOID SubjectKey StudyEventOID StudyEventRepeatKey ItemGroupRepeatKey; if first.ItemGroupRepeatKey then do; LBDTC=''; end; if ItemOID='IT.LB.LBDTC' then LBDTC=Value; if last.ItemGroupRepeatKey then output;run;proc sql;create table joined as select a.*,b.LBDTC from odm a inner join dates b on a.StudyOID=b.StudyOID and a.SubjectKey=b.SubjectKey and a.StudyEventOID=b.StudyEventOID and a.StudyEventRepeatKey=b.StudyEventRepeatKey and a.ItemGroupRepeatKey=b.ItemGroupRepeatKey where a.ItemOID in ('IT.LB.CALCIUM','IT.LB.CREAT') and not missing(a.Value); quit;data prepared; set joined; length DOMAIN $2 STUDYID USUBJID LBTESTCD LBTEST LBORRES LBORRESU LBSTRESU LBSTAT $1024;DOMAIN='LB'; STUDYID=StudyOID; USUBJID=SubjectKey; LBORRES=Value; LBORRESU='mg/dL'; LBSTRESU='mg/dL'; LBSTRESN=.; LBSTAT='';if Value ne 'NOT DONE' then LBSTRESN=input(Value,?? best32.);if ItemOID='IT.LB.CREAT' then do; LBTESTCD='CREAT'; LBTEST='Creatinine'; end; else do; LBTESTCD='CA'; LBTEST='Calcium'; end;if Value='NOT DONE' then do; LBORRES=''; LBORRESU=''; LBSTRESU=''; LBSTRESN=.; LBSTAT='NOT DONE'; end; run;proc sort data=prepared; by STUDYID USUBJID LBDTC LBTESTCD; run;data result; set prepared; by STUDYID USUBJID; retain LBSEQ; if first.USUBJID then LBSEQ=0; LBSEQ+1;run;proc sql; create table final as select DOMAIN, STUDYID, USUBJID, LBSEQ, LBTESTCD, LBTEST, LBORRES, LBORRESU, LBSTRESN, LBSTRESU, LBSTAT, LBDTC from result;quit;proc export data=final outfile="/app/output/lb.csv" dbms=csv replace; run;
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