Review ask

As a clinical trial statistician or programmer, challenge anything in this benchmark: describe a problem in Comments, or propose a fix with the Edit button on any source file.

  1. Task: Would a real study need this derivation, specified this way? Does it follow CDISC ADaM: variable names, controlled terms, record structure? Flag any rule that is ambiguous or that a sponsor would handle differently.
  2. Inputs: Do they look like data collected in a real trial, and do they include the situations you would expect to meet in one?
  3. Expected output: Would independent QC programming reproduce every value from these inputs and rules?

The other tabs beside Comments are background for assessment, not under review.

Summary

Lifecycle: draftEditUnder review
What this benchmark means
README.md

Goal: show where each column of the artifact comes from: the artifact carries exactly the columns the specification declares, and every declared column has a stated value, whether it is computed once for all rows or separately by each row template.

Input: one spec.yaml over one lab-results file. Each record carries a subject (USUBJID), a visit (VISIT), a test code (ALT or AST), and a result that arrives as text. The file also carries a sequencing field the specification never declares.

Variables:

  • PARAM: the test's full name (Alanine Aminotransferase for ALT, Aspartate Aminotransferase for AST), or Lowest Result of Visit on the summary rows.
  • AVISIT: the visit's display name (WEEK 1 DAY 1, WEEK 2 DAY 8); the summary rows replace it with OVERALL.
  • AVAL: the result as a number.
  • DTYPE: empty on the component rows; LOWEST on the summary rows.
  • FLAG: H when the result is above 60, else N.

Note: the undeclared sequencing field never reaches the artifact, and the working value behind FLAG is checked for completeness but stays out of the artifact.

Inputs

Under review
1 source file

input/lb.csv

Edit
7 rows
input/lb.csv
USUBJIDVISITLBTESTCDLBSTRESNRAWSEQ
1ALT32r1
1AST45r2
2ALT28r3
2AST60r4
1ALT90r5
1AST70r6
2ALT—r7

Expected output

Under review
9 expected rows

expected/adlb.csv

Edit
9 rows
expected/adlb.csv
STUDYIDUSUBJIDVISITPARAMCDPARAMAVISITAVALDTYPEFLAG
YAMAA-011ALTAlanine AminotransferaseWEEK 1 DAY 132—N
YAMAA-011ASTAspartate AminotransferaseWEEK 1 DAY 145—N
YAMAA-012ALTAlanine AminotransferaseWEEK 2 DAY 828—N
YAMAA-012ASTAspartate AminotransferaseWEEK 2 DAY 860—N
YAMAA-011ALTAlanine AminotransferaseWEEK 1 DAY 190—H
YAMAA-011ASTAspartate AminotransferaseWEEK 1 DAY 170—H
YAMAA-011LOWLowest Result of VisitOVERALL32LOWESTN
YAMAA-012LOWLowest Result of VisitOVERALL28LOWESTN
YAMAA-011LOWLowest Result of VisitOVERALL70LOWESTH
Shaded columns are derived— = missing value

Comments and assessment materials

Comments

Signed in with GitHub; saved in repository Discussions

Mapping spec

Generated from the benchmark YAML; do not edit by hand

Dataset NameVariable NameVariable LabelTypeCodelist/Controlled TermsCoreComputational MethodOrigin
ADLBSTUDYIDStudy IdentifiercharacterSet constant value "YAMAA-01".Assigned
ADLBUSUBJIDUnique Subject IdentifiercharacterCopy value from LB.USUBJID.Predecessor
ADLBVISITVisit NumbernumericCopy value from LB.VISIT.Predecessor
ADLBPARAMCDParameter CodecharacterSet per constructed row; see the Row construction sheet.Derived
ADLBPARAMParametercharacterSet per constructed row; see the Row construction sheet.Derived
ADLBAVISITAnalysis VisitcharacterSet per constructed row; see the Row construction sheet.Derived
ADLBAVALAnalysis ValuenumericSet per constructed row; see the Row construction sheet.Derived
ADLBDTYPEDerivation TypecharacterSet per constructed row; see the Row construction sheet.Derived
ADLBFLAGHigh Value FlagcharacterIf HIGH = 1 then "H"; otherwise "N".Derived
TemplateInclude whenPARAMCDPARAMAVISITAVALDTYPE
componentsLB.LBSTRESN IS NOT NULLCopy LB.LBTESTCDIf LB.LBTESTCD = 'ALT' then "Alanine Aminotransferase"; otherwise "Aspartate Aminotransferase"If LB.VISIT = 1 then "WEEK 1 DAY 1"; otherwise "WEEK 2 DAY 8"Copy LB.LBSTRESNConstant "None"
visit_lowAVAL IS NOT NULLConstant "LOW"Constant "Lowest Result of Visit"Constant "OVERALL"Aggregate MIN(LB.LBSTRESN) over records matching on the shared output keysConstant "LOWEST"
VersionDateAuthorDescriptionReviewerSign-off
1.32026-09-29yamaa docs buildShow study codelist names, external dictionaries, and ISO 8601 formats in variable rows; list the document's codelist values and metadata
1.22026-09-29yamaa docs buildClassify ADaM copies from a declared input as Predecessor and recodes as Derived, and SDTM recodes of locally derived columns as Derived
1.12026-09-29yamaa docs buildResolve lookups into the donor record they select, and give every derivation shape a plain-language rule instead of its raw YAML
1.0yamaa docs buildInitial generation from spec.yaml

yamaa code

Runs the yamaa specification; its result must match the expected output

run.R

Edit
4 lines
library(yamaa)adlb <- yamaa_domain("spec.yaml")$outputadlb

run.py

Edit
4 lines
import yamaaadlb = yamaa.yamaa_domain("spec.yaml").outputadlb